|
KMID : 1120320190050020057
|
|
Osteoporosis and Sarcopenia
2019 Volume.5 No. 2 p.57 ~ p.61
|
|
|
Additive effects of eldecalcitol in poorly responding long-term bisphosphonate treatment for osteoporosis
|
|
Kamimura Mikio
Ikegami Shota
Mukaiyama Keijiro
Koiwai Hidefumi
Nakamura Yukio
Taguchi Akira
Kato Hiroyuki
|
|
|
Abstract
|
|
|
Objectives: We examined whether eldecalcitol (ELD) provided additive bone mineral density (BMD) and bone turnover marker gains in patients undergoing long-term bisphosphonate (BP) usage, especially in osteoporotic individuals exhibiting a poor response to BPs.
Methods: Forty-two post-menopausal patients with primary osteoporosis and low lumbar BMD (L-BMD) and/or bilateral total hip BMD (H-BMD) values receiving long-term BP treatment were prospectively enrolled. Serum bone alkaline phosphatase (BAP) was measured as a bone formation marker and urinary N-terminal telopeptide of type I collagen (NTX) was assessed as a bone resorption marker. L-BMD, H-BMD, and femoral neck BMD (N-BMD) were recorded before, at the commencement of, and during ELD administration.
Results: BAP and urinary NTX were significantly decreased by BP therapy prior to ELD. ELD addition further significantly decreased the bone turnover markers (both p?
Conclusions: This study suggests that ELD addition may be useful for osteoporotic patients exhibiting a diminished long-term BP therapy response.
|
|
|
KEYWORD
|
|
|
Bisphosphonate, Bone mineral density, Eldecalcitol, Osteoporosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|